Think of it like trying to fit a USB-A plug into a USB-C port—physically incompatible. Cats (Felis catus) and dogs (Canis lupus familiaris) are separated by millions of years of evolution.
Their chromosome counts don’t match at all. Cats have 19 pairs of chromosomes, while dogs have 39—a genetic gap so wide that fertilization is biologically impossible.
Even if, by some sci-fi miracle, a sperm met an egg, the DNA would be too different to create a viable embryo. Nature’s firewall is impressively strict here.