Some budget airlines will try to charge you for the extra bag. Don't pay it. Flash your best "I have a medical condition" face and politely cite the Air Carrier Access Act. They fold faster than a cheap suitcase.
Also, check if your plane has a special medical outlet under the seat. Most CPAP machines are approved for use on planes—yes, you can wear it during the flight. Imagine the looks from other passengers as you transform into Darth Vader mid-cabin. One guy next to me asked if I was "hacking the flight system." I told him I was rebooting my lungs.
The Humidifier Taboo
If you plan to use the CPAP on the plane, do not fill the humidifier. The air pressure changes will turn that water into a miniature tsunami inside your bag. Empty the tank completely, or you'll be that person whose luggage weeps on the conveyor belt.
But here's a surprising fact: you can actually buy a CPAP that runs on a battery pack. Yes, you can charge it like your phone. Just don’t try to power it from the plane’s USB port, or you’ll blow the fuse for the entire economy class. It happened to a friend. He was banned from Delta for "recreational electricity abuse."
Can You Bring Your Cpap Machine On A Plane | Detroit Chinatown